Association of rs1006737 in CACNA1C with alterations in prefrontal activation and fronto-hippocampal connectivity.

ABSTRACT:

Background

Genome-wide association studies have identified the rs1006737 single nucleotide polymorphism (SNP) in the CACNA1C gene as a susceptibility locus for schizophrenia and bipolar disorder. On the neural systems level this association is explained by altered functioning of the dorsolateral prefrontal cortex (DLPFC) and the hippocampal formation (HF), brain regions also affected by mental illness. In the present study we investigated the association of rs1006737 genotype with prefrontal activation and fronto-hippocampal connectivity.

Methods

We used functional magnetic resonance imaging to measure neural activation during an n-back working memory task in 94 healthy subjects. All subjects were genotyped for the SNP rs1006737. We tested associations of the rs1006737 genot

SUBMITTER: Paulus FM 

PROVIDER: S-EPMC6869796 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature