Tissue-specific tumor microenvironments influence responses to immunotherapies.

ABSTRACT:

Objectives

Investigation of variable response rates to cancer immunotherapies has exposed the immunosuppressive tumor microenvironment (TME) as a limiting factor of therapeutic efficacy. A determinant of TME composition is the tumor location, and clinical data have revealed associations between certain metastatic sites and reduced responses. Preclinical models to study tissue-specific TMEs have eliminated genetic heterogeneity, but have investigated models with limited clinical relevance.

Methods

We investigated the TMEs of tumors at clinically relevant sites of metastasis (liver and lungs) and their impact on αPD-1/αCTLA4 and trimAb (αDR5, α4-1BB, αCD40) therapy responses in the 67NR mouse breast cancer and Renca mouse kidney cancer models.

Results

Tumors grown in th

SUBMITTER: Oliver AJ 

PROVIDER: S-EPMC6869967 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature