Disturbed cortico-subcortical interactions during motor task switching in traumatic brain injury.

ABSTRACT: The ability to suppress and flexibly adapt motor behavior is a fundamental mechanism of cognitive control, which is impaired in traumatic brain injury (TBI). Here, we used a combination of functional magnetic resonance imaging and diffusion weighted imaging tractography to study changes in brain function and structure associated with motor switching performance in TBI. Twenty-three young adults with moderate-severe TBI and twenty-six healthy controls made spatially and temporally coupled bimanual circular movements. A visual cue signaled the right hand to switch or continue its circling direction. The time to initiate the switch (switch response time) was longer and more variable in the TBI group and TBI patients exhibited a higher incidence of complete contralateral (left hand) movement d

SUBMITTER: Leunissen I 

PROVIDER: S-EPMC6870055 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature