Dissociating anticipation from perception: Acute pain activates default mode network.

ABSTRACT: Few studies have explored the effect of acute pain on attentional networks and on the default mode network. Moreover, these studies convey conflicting results, seemingly caused by design. To reassess this issue, we studied 20 healthy subjects with functional magnetic resonance imaging while delivering painful electric shocks. The design was purposely constructed to separate rest, anticipation, and pain perception. We found that default mode network activity in response to pain was biphasic. It deactivated during anticipation when the dorsal attentional network was activated. During pain perception, the default mode network was activated, as were attentional networks. The left posterior fusiform gyrus showed the same dynamics as the default mode network, and its activity was negatively corr

SUBMITTER: Ter Minassian A 

PROVIDER: S-EPMC6870109 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature