Effect of D-amino acid oxidase activator (DAOA; G72) on brain function during verbal fluency.

ABSTRACT:

Background

The D-Amino acid oxidase activator (G72 or DAOA) is believed to play a key role in the regulation of central glutamatergic transmission which is seen to be altered in psychosis. It is thought to regulate D-amino acid oxidase (DAO), which metabolizes D-serine, a co-agonist of NMDA-type glutamate receptors and to be involved in dendritic arborization. Linkage, genetic association and expression studies have implicated the G72 gene in both schizophrenia and bipolar disorder.

Aims

To examine the influence of G72 variation on brain function in the healthy population.

Method

Fifty healthy volunteers were assessed using functional magnetic resonance imaging while performing a verbal fluency task. Regional brain activation and task-dependent functional connectivity

SUBMITTER: Prata DP 

PROVIDER: S-EPMC6870192 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature