Effects of rapid eye movement sleep deprivation on fear extinction recall and prediction error signaling.

ABSTRACT: In a temporal difference learning approach of classical conditioning, a theoretical error signal shifts from outcome deliverance to the onset of the conditioned stimulus. Omission of an expected outcome results in a negative prediction error signal, which is the initial step towards successful extinction and may therefore be relevant for fear extinction recall. As studies in rodents have observed a bidirectional relationship between fear extinction and rapid eye movement (REM) sleep, we aimed to test the hypothesis that REM sleep deprivation impairs recall of fear extinction through prediction error signaling in humans. In a three-day design with polysomnographically controlled REM sleep deprivation, 18 young, healthy subjects performed a fear conditioning, extinction and recall of extinct

SUBMITTER: Spoormaker VI 

PROVIDER: S-EPMC6870311 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature