The 5-HTTLPR polymorphism is associated with altered hemodynamic responses during appetitive conditioning.

ABSTRACT:

Background

Current models suggest that a variation in the promoter region of the serotonin transporter gene (5-HTTLPR) is associated with altered amygdala reactivity not only towards negative but also towards positive stimuli, which has been neglected in the past. This association may possibly convey an elevated vulnerability for psychopathology like abuse, craving, and relapses. Since appetitive conditioning is a crucial mechanism in the pathogenesis of these psychiatric disorders, the identification of specific factors contributing to interindividual variation is important.

Methods

In the present study (N = 86), an appetitive conditioning paradigm was conducted, in which a neutral stimulus (CS+) was associated with appetitive stimuli, while a second stimulus (CS-) predicte

SUBMITTER: Klucken T 

PROVIDER: S-EPMC6870347 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature