FMRI study of mesial temporal lobe epilepsy using amplitude of low-frequency fluctuation analysis.

ABSTRACT: Various functional imaging tools have been used to detect epileptic activity in the neural network underlying mesial temporal lobe epilepsy (mTLE). In the present fMRI study, a data-driven approach was employed to map interictal epileptic activity in mTLE patients by measuring the amplitude of low-frequency fluctuation (ALFF) of the blood oxygen level-dependent (BOLD) signal. Twenty-four left mTLE patients and 26 right mTLE patients were investigated by comparing with 25 healthy subjects. In the patients, the regions showing increased ALFF were consistently distributed in the mesial temporal lobe, thalamus, and a few of other cortical and subcortical structures composing a mesial temporal epilepsy network proposed previously, while the regions showing decreased ALFF were mostly located in

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC6870704 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature