Electroencephalographic slow wave dynamics and loss of behavioural responsiveness induced by ketamine in human volunteers.

ABSTRACT:

Background

Previous work on the electroencephalographic (EEG) effects of anaesthetic doses of ketamine has identified a characteristic signature of increased high frequency (beta-gamma) and theta waves alternating with episodic slow waves. It is unclear which EEG parameter is optimal for pharmacokinetic-pharmacodynamic modelling of the hypnotic actions of ketamine, or which EEG parameter is most closely linked to loss of behavioural responsiveness.

Methods

We re-analysed previously published 128-channel scalp EEG data from 15 subjects who had received a 1.5 mg kg^-1 bolus i.v. dose of ketamine. We applied standard sigmoid pharmacokinetic-pharmacodynamic models to the drug-induced changes in slow wave activity, theta, and beta-gamma EEG power; and examined the morph

SUBMITTER: Sleigh J 

PROVIDER: S-EPMC6871266 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature