Selective effects of isoflurane on cortico-cortical feedback afferent responses in murine non-primary neocortex.

ABSTRACT:

Background

General anaesthetics affect loss of consciousness by disrupting information-passing and integration within thalamo-cortical (TC) networks. Feedback cortical connections that carry internally generated signals such as expectation and attention appear more sensitive to anaesthesia than feedforward signals. However, direct evidence for this effect in non-primary cortex is lacking. In addition, direct comparisons between TC core and matrix, and between cortico-cortical (CC) feedforward and feedback responses have not been reported.

Methods

We investigated the disruption of synaptic responses by isoflurane of four distinct afferent pathways to non-primary neocortex. We independently activated TC core and matrix and reciprocal CC (feedforward and feedback) pathways usin

SUBMITTER: Murphy C 

PROVIDER: S-EPMC6871270 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature