Global, pathway and gene coverage of three Illumina arrays with respect to inflammatory and immune-related pathways.

ABSTRACT: Genome-wide association studies have led in the past to the discovery of susceptibility genes for many diseases including cancer and inflammatory conditions. However, a number of these studies did not realise their full potential. A first critical step in developing such large-scale studies is the choice of genotyping array with respect to the study goal. Coverage is the central criterion for array evaluation. We distinguish between estimates of global coverage across the genome, coverage for each chromosome, coverage for selected pathways and the coverage for genes of interest. Here, we focus on inflammatory and immunological pathways and genes relevant for haematopoietic stem cell transplantation. We compared three arrays: the Infinium Global Screening Array-24 v1.0, the Infinium OncoArr

SUBMITTER: Tozzi V 

PROVIDER: S-EPMC6871524 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature