Fractionated Proton Beam Therapy for Acoustic Neuromas: Tumor Control and Hearing Preservation.

ABSTRACT:

Purpose

This prospective cohort evaluated patients with acoustic neuroma treated with proton irradiation at Loma Linda University Medical Center. A dose of 50.4 Gy in 28 fractions was given to improve hearing preservation while maintaining tumor control.

Patients and methods

Ninety-five patients were treated from March 1991 to March 2008. Fractionated proton radiotherapy at daily doses of 1.8 Gy was employed. Patients were treated to 1 of 3 total doses: 59.4 Gy, used initially for patients without serviceable hearing; 54 Gy, used for patients with serviceable hearing through October 2000; and 50.4 Gy used since 2001 for patients with serviceable hearing. Survival and local control were calculated using the Kaplan-Meier method. Logistic regression analysis was preformed compa

SUBMITTER: Barnes CJ 

PROVIDER: S-EPMC6871573 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature