Proton Irradiation with Hyperthermia in Unresectable Soft Tissue Sarcoma.

ABSTRACT:

Purpose

Unresectable soft tissue sarcomas (STSs) do not usually exhibit significant tumor downstaging with preoperative radiotherapy and/or chemotherapy due to their limited radiosensitivity/chemosensitivity. Limb amputations for tumors of the extremities inevitably lead to considerable loss of function and impairment in quality of life. Local hyperthermia at 39°C to 43°C and proton irradiation combine thermoradiobiological and physical dose distribution advantages, possibly mimicking those of a ¹²C ion therapy. We report the first 2 patients treated with this unique approach of proton thermoradiotherapy.

Materials and methods

Both patients had an unresectable STS of the left lower leg (1 grade 2 myxoid fibrosarcoma, 1 grade 3 undifferentiated pleomorphic sarcoma)

SUBMITTER: Datta NR 

PROVIDER: S-EPMC6871610 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature