A population of bang-bang switches of defective interfering particles makes within-host dynamics of dengue virus controllable.

ABSTRACT: The titre of virus in a dengue patient and the duration of this viraemia has a profound effect on whether or not a mosquito will become infected when it feeds on the patient and this, in turn, is a key driver of the magnitude of a dengue outbreak. The assessment of the heterogeneity of viral dynamics in dengue-infected patients and its precise treatment are still uncertain. Infection onset, patient physiology and immune response are thought to play major roles in the development of the viral load. Research has explored the interference and spontaneous generation of defective virus particles, but have not examined both the antibody and defective particles during natural infection. We explore the intrinsic variability in the within-host dynamics of viraemias for a population of patients usin

SUBMITTER: Mapder T 

PROVIDER: S-EPMC6872170 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature