Transcriptional and genomic parallels between the monoxenous parasite Herpetomonas muscarum and Leishmania.

ABSTRACT: Trypanosomatid parasites are causative agents of important human and animal diseases such as sleeping sickness and leishmaniasis. Most trypanosomatids are transmitted to their mammalian hosts by insects, often belonging to Diptera (or true flies). These are called dixenous trypanosomatids since they infect two different hosts, in contrast to those that infect just insects (monoxenous). However, it is still unclear whether dixenous and monoxenous trypanosomatids interact similarly with their insect host, as fly-monoxenous trypanosomatid interaction systems are rarely reported and under-studied-despite being common in nature. Here we present the genome of monoxenous trypanosomatid Herpetomonas muscarum and discuss its transcriptome during in vitro culture and during infection of its natural

SUBMITTER: Sloan MA 

PROVIDER: S-EPMC6872171 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature