Physiologic Insights from the COPD Genetic Epidemiology Study.

ABSTRACT: COPD Genetic Epidemiology Study (COPDGene^®) manuscripts have provided important insights into chronic obstructive pulmonary disease (COPD) pathophysiology and outcomes, including a better understanding of COPD phenotypes relating computed tomography (CT) anatomic data to spirometric and patient-reported outcomes. Spirometry significantly underdiagnoses smoking-induced lung disease, and there is a marked improvement in sensitivity and specificity with CT scanning. This review also highlights the COPDGene^® exploration of specific spirometry phenotypes (e.g.,PRISm), contributors to spirometric decline, composite physiologic measures, asthma-COPD overlap (ACO) syndrome, consequences of bronchodilator responsiveness, newer methods to assess small airway dysfunction, and sp

SUBMITTER: Stringer WW 

PROVIDER: S-EPMC6872216 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature