Indomethacin for intracranial hypertension secondary to severe traumatic brain injury in adults.

ABSTRACT:

Background

Among people who have suffered a traumatic brain injury, increased intracranial pressure continues to be a major cause of early death; it is estimated that about 11 people per 100 with traumatic brain injury die. Indomethacin (also known as indometacin) is a powerful cerebral vasoconstrictor that can reduce intracranial pressure and, ultimately, restore cerebral perfusion and oxygenation. Thus, indomethacin may improve the recovery of a person with traumatic brain injury.

Objectives

To assess the effects of indomethacin for adults with severe traumatic brain injury.

Search methods

We ran the searches from inception to 23 August 2019. We searched the Cochrane Central Register of Controlled Trials (CENTRAL; 2019, Issue 8) in the Cochrane Library, Ovid MEDLINE

SUBMITTER: Martin-Saborido C 

PROVIDER: S-EPMC6872435 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature