Oncoviruses Can Drive Cancer by Rewiring Signaling Pathways Through Interface Mimicry.

ABSTRACT: Oncoviruses rewire host pathways to subvert host immunity and promote their survival and proliferation. However, exactly how is challenging to understand. Here, by employing the first and to date only interface-based host-microbe interaction (HMI) prediction method, we explore a pivotal strategy oncoviruses use to drive cancer: mimicking binding surfaces-interfaces-of human proteins. We show that oncoviruses can target key human network proteins and transform cells by acquisition of cancer hallmarks. Experimental large-scale mapping of HMIs is difficult and individual HMIs do not permit in-depth grasp of tumorigenic virulence mechanisms. Our computational approach is tractable and 3D structural HMI models can help elucidate pathogenesis mechanisms and facilitate drug design. We observe tha

SUBMITTER: Guven-Maiorov E 

PROVIDER: S-EPMC6872517 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature