MicroRNA expression in the cerebrospinal fluid of dogs with and without cervical spondylomyelopathy.

ABSTRACT:

Background

Osseous-associated cervical spondylomyelopathy (OA-CSM) is a common condition of the cervical vertebral column that affects giant dog breeds. MicroRNAs (miRNAs) are small RNAs that regulate gene expression, and recent data suggest that circulating miRNAs present in biological fluids may serve as potential biomarkers for disease. The miRNA profiles of cerebrospinal fluid (CSF) from healthy dogs and dogs clinically affected by OA-CSM have not been described.

Objective

To characterize the expression levels of miRNAs present in the CSF of normal Great Danes and identify differentially expressed miRNAs in the CSF of Great Danes clinically affected with OA-CSM.

Animals

Client-owned dogs: 12 control, 12 OA-CSM affected.

Methods

Cerebrospinal fluid samples w

SUBMITTER: Vansteenkiste DP 

PROVIDER: S-EPMC6872614 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature