Sequence-Derived Markers of Drug Targets and Potentially Druggable Human Proteins.

ABSTRACT: Recent research shows that majority of the druggable human proteome is yet to be annotated and explored. Accurate identification of these unexplored druggable proteins would facilitate development, screening, repurposing, and repositioning of drugs, as well as prediction of new drug-protein interactions. We contrast the current drug targets against the datasets of non-druggable and possibly druggable proteins to formulate markers that could be used to identify druggable proteins. We focus on the markers that can be extracted from protein sequences or names/identifiers to ensure that they can be applied across the entire human proteome. These markers quantify key features covered in the past works (topological features of PPIs, cellular functions, and subcellular locations) and several nove

SUBMITTER: Ghadermarzi S 

PROVIDER: S-EPMC6872670 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature