Estimated dead space fraction and the ventilatory ratio are associated with mortality in early ARDS.

ABSTRACT:

Background

Indirect indices for measuring impaired ventilation, such as the estimated dead space fraction and the ventilatory ratio, have been shown to be independently associated with an increased risk of mortality. This study aimed to compare various methods for dead space estimation and the ventilatory ratio in patients with acute respiratory distress syndrome (ARDS) and to determine their independent values for predicting death at day 30. The present study is a post hoc analysis of a prospective observational cohort study of ICUs of two tertiary care hospitals in the Netherlands.

Results

Individual patient data from 940 ARDS patients were analyzed. Estimated dead space fraction and the ventilatory ratio at days 1 and 2 were significantly higher among non-survivors (p < 0

SUBMITTER: Morales-Quinteros L 

PROVIDER: S-EPMC6872683 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature