Dataset Information

Development and evaluation of a health-related quality-of-life tool for dogs with Cushing's syndrome.

ABSTRACT:

Background

Clinical signs and consequences of Cushing's syndrome are likely to impact upon a dog's life. Quantification of this impact on a dog's health-related quality-of-life (HRQoL) could contribute to optimized disease management.

Hypothesis/objectives

To develop a novel HRQoL tool to aid assessment of dogs with Cushing's syndrome and to evaluate factors that impact upon dogs living with this disease.

Animals

Two hundred and ten dogs with Cushing's syndrome and 617 dogs without Cushing's syndrome.

Methods

Cross-sectional study design. Dog owners answered questions relating to the HRQoL of their dogs which were refined to develop the final tool. The tool was analyzed for reliability, validity, and interpretability, including Cronbach's alpha and principal components analysis. Factors impacting upon the HRQoL of dogs with Cushing's syndrome were assessed using appropriate nonparametric tests.

Results

The tool was refined from 32 questions to 19 and showed good internal consistency (α = .83). Owners rated questions related to "owner impact" as more important and those related to demeanor as less important. There was a positive correlation between the tool score of dogs with Cushing's syndrome and owner's assessment of their dog's quality-of-life (r = .41, P < .001). Dogs currently on treatment with trilostane had a statistically better HRQoL (.33, interquartile range [IQR] .23-.44) than those not receiving trilostane (.36, IQR .33-.54, P = .04).

Conclusions and clinical importance

The developed tool quantifies the HRQoL of dogs with Cushing's syndrome and could assist clinicians in the clinical assessment of dogs with Cushing's syndrome.

SUBMITTER: Schofield I

PROVIDER: S-EPMC6872869 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature

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Publications

Development and evaluation of a health-related quality-of-life tool for dogs with Cushing's syndrome.

Schofield Imogen I O'Neill Dan G DG Brodbelt Dave C DC Church David B DB Geddes Rebecca F RF Niessen Stijn J M SJM

Journal of veterinary internal medicine 20191029 6

<h4>Background</h4>Clinical signs and consequences of Cushing's syndrome are likely to impact upon a dog's life. Quantification of this impact on a dog's health-related quality-of-life (HRQoL) could contribute to optimized disease management.<h4>Hypothesis/objectives</h4>To develop a novel HRQoL tool to aid assessment of dogs with Cushing's syndrome and to evaluate factors that impact upon dogs living with this disease.<h4>Animals</h4>Two hundred and ten dogs with Cushing's syndrome and 617 dogs ...[more]

PMID: 31660657

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Dataset Information

Development and evaluation of a health-related quality-of-life tool for dogs with Cushing's syndrome.

Background

Hypothesis/objectives

Animals

Methods

Results

Conclusions and clinical importance

Publications

Development and evaluation of a health-related quality-of-life tool for dogs with Cushing's syndrome.

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