Levothyroxine treatment and incident dementia in adults with atrial fibrillation.

ABSTRACT:

Objective

Levothyroxine treatment is common among older adults as is atrial fibrillation (AF), yet less is known about its potential effects on the development of dementia.

Methods

The study population included all adults with diagnosed AF (n = 156,104) aged ≥ 45 years in Sweden without an earlier recorded diagnosis of dementia. Individuals with a dispensed prescription of levothyroxine on two or more occasions between July 1 2005 and December 31 2006 in Sweden were considered exposed (n = 12,978; 8.3%), and were compared to all other patients with AF without this treatment. Cox regression with hazard ratios (HRs) and 95% confidence interval (95% CI), with outcome defined as dementia of all causes between January 1, 2007 and December 31, 2015, was used in the analysis. Adjus

SUBMITTER: Wandell P 

PROVIDER: S-EPMC6872912 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature