Turning it inside out: The organization of human septin heterooligomers.

ABSTRACT: Septin family proteins are quite similar to each other both within and between eukaryotic species. Typically, multiple discrete septins co-assemble into linear heterooligomers (usually hexameric or octameric rods) with a variety of cellular functions. We know little about how incorporation of different septins confers different properties to such complexes. This issue is especially acute in human cells where 13 separate septin gene products (often produced in multiple forms arising from alternative start codons and differential splicing) are expressed in a tissue-specific manner. Based on sequence alignments and phylogenetic criteria, human septins fall into four distinct groups predictive of their interactions, that is, members of the same group appear to occupy the same position within o

SUBMITTER: McMurray MA 

PROVIDER: S-EPMC6872917 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature