Staging of Schizophrenia With the Use of PANSS: An International Multi-Center Study.

ABSTRACT:

Introduction

A specific clinically relevant staging model for schizophrenia has not yet been developed. The aim of the current study was to evaluate the factor structure of the PANSS and develop such a staging method.

Methods

Twenty-nine centers from 25 countries contributed 2358 patients aged 37.21 ± 11.87 years with schizophrenia. Analysis of covariance, Exploratory Factor Analysis, Discriminant Function Analysis, and inspection of resultant plots were performed.

Results

Exploratory Factor Analysis returned 5 factors explaining 59% of the variance (positive, negative, excitement/hostility, depression/anxiety, and neurocognition). The staging model included 4 main stages with substages that were predominantly characterized by a single domain of symptoms (stage 1: pos

SUBMITTER: Fountoulakis KN 

PROVIDER: S-EPMC6872964 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature