WDR5 inhibition halts metastasis dissemination by repressing the mesenchymal phenotype of breast cancer cells.

ABSTRACT:

Background

Development of metastases and drug resistance are still a challenge for a successful systemic treatment in breast cancer (BC) patients. One of the mechanisms that confer metastatic properties to the cell relies in the epithelial-to-mesenchymal transition (EMT). Moreover, both EMT and metastasis are partly modulated through epigenetic mechanisms, by repression or induction of specific related genes.

Methods

We applied shRNAs and drug targeting approaches in BC cell lines and metastatic patient-derived xenograft (PDX) models to inhibit WDR5, the core subunit of histone H3 K4 methyltransferase complexes, and evaluate its role in metastasis regulation.

Result

We report that WDR5 is crucial in regulating tumorigenesis and metastasis spreading during BC progressi

SUBMITTER: Punzi S 

PROVIDER: S-EPMC6873410 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature