Genetic variants in humanin nuclear isoform gene regions show no association with coronary artery disease.

ABSTRACT:

Objective

Coronary artery disease contributes to noncommunicable disease deaths worldwide. In order to make preventive methods more accurate, we need to know more about the development and progress of this pathology, including the genetic aspects. Humanin is a small peptide known for its cytoprotective and anti-apoptotic properties. Our study looked for genomic associations between humanin-like nuclear isoform genes and coronary artery disease using CARDIoGRAMplusC4D Consortium data.

Results

Lookup from meta-analysis datasets gave single nucleotide polymorphisms in all 13 humanin-like nuclear isoform genes with the lowest P value for rs6151662 from the MTRNR2L2 gene including the 50 kb flanking region in both directions (P-value = 0.0037). Within the gene region alone the to

SUBMITTER: Eltermaa M 

PROVIDER: S-EPMC6873426 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature