Common polymorphic inversions at 17q21.31 and 8p23.1 associate with cancer prognosis.

ABSTRACT:

Background

Chromosomal inversions are structural genetic variants where a chromosome segment changes its orientation. While sporadic de novo inversions are known genetic risk factors for cancer susceptibility, it is unknown if common polymorphic inversions are also associated with the prognosis of common tumors, as they have been linked to other complex diseases. We studied the association of two well-characterized human inversions at 17q21.31 and 8p23.1 with the prognosis of lung, liver, breast, colorectal, and stomach cancers.

Results

Using data from The Cancer Genome Atlas (TCGA), we observed that inv8p23.1 was associated with overall survival in breast cancer and that inv17q21.31 was associated with overall survival in stomach cancer. In the meta-analysis of two independ

SUBMITTER: Ruiz-Arenas C 

PROVIDER: S-EPMC6873427 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature