The Commensal Neisseria musculi Modulates Host Innate Immunity To Promote Oral Colonization.

ABSTRACT: Neisseria musculi, isolated from the oral cavity of wild-caught mice, does not colonize most inbred mouse strains. N. musculi does weakly (50%) colonize C57BL/6J (B6) mice but readily colonizes CAST/EiJ (CAST) mice. In this study, we examined whether differences in the CAST and B6 host response could elucidate mechanisms governing N. musculi colonization. In vivo stimulation of B6 or CAST splenocytes with wild type (WT) Neisseria or Escherichia coli LPS showed that CAST mice had a blunted inflammatory response, producing significantly lower levels of IL-6 than B6 mice. The use of specific genetic knockouts highlighted a need for an intact innate immune system to prevent colonization. B6-RAG-1^-/- mice were colonized at a similar rate as WT B6 mi

SUBMITTER: Powell DA 

PROVIDER: S-EPMC6873461 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature