Risk factors for valvular calcification.

ABSTRACT: PURPOSE OF REVIEW:Recent literature is examined to identify established and emerging risk factors for valvular calcification, specifically calcific aortic valve disease and mitral annular calcification. RECENT FINDINGS:Strong evidence implicates older age, male sex, cigarette smoking, elevated blood pressure, dyslipidaemia, adiposity, and mineral metabolism as risk factors for calcific aortic valve disease. Emerging evidence suggests family history and lipoprotein(a) are additional risk factors. Recently, large-scale genome-wide analyses have identified robust associations for LPA, PALMD, and TEX41 with aortic stenosis. Factors predisposing to mitral annular calcification are less well characterized. Older age, cigarette smoking, increased BMI, kidney dysfunction, and elevated triglyceride

SUBMITTER: Chen HY 

PROVIDER: S-EPMC6873465 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature