Prognostic and diagnostic significance of galectins in pancreatic cancer: a systematic review and meta-analysis.

ABSTRACT:

Background

Galectins constitute a family of β-galactoside-binding proteins, which influence various hallmarks of pancreatic cancer, including cell proliferation, invasion and migration; immune escape; and angiogenesis. Although many studies have concentrated on the role of galectins in pancreatic cancer, the results remain controversial. Hence, we performed a comprehensive meta-analysis to clarify the precise diagnostic and prognostic value of galectins in pancreatic cancer.

Methods

PubMed/MEDLINE, EMBASE and Web of Science were used to search related published literature up to July 2019. Pooled hazard ratios (HRs), diagnostic accuracy variables and related 95% confidence intervals (CIs) were calculated using STATA 14.0 software.

Results

Eleven studies including 1227

SUBMITTER: Sun Q 

PROVIDER: S-EPMC6873495 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature