Analyses of inter-individual variations of sperm DNA methylation and their potential implications in cattle.

ABSTRACT:

Background

DNA methylation has been shown to be involved in many biological processes, including X chromosome inactivation in females, paternal genomic imprinting, and others.

Results

Based on the correlation patterns of methylation levels of neighboring CpG sites among 28 sperm whole genome bisulfite sequencing (WGBS) data (486 × coverage), we obtained 31,272 methylation haplotype blocks (MHBs). Among them, we defined conserved methylated regions (CMRs), variably methylated regions (VMRs) and highly variably methylated regions (HVMRs) among individuals, and showed that HVMRs might play roles in transcriptional regulation and function in complex traits variation and adaptive evolution by integrating evidence from traditional and molecular quantitative trait loci (QTL), and s

SUBMITTER: Liu S 

PROVIDER: S-EPMC6873545 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature