Effects of prostaglandin F_2α (PGF_2α) on cell-death pathways in the bovine corpus luteum (CL).

ABSTRACT:

Background

Prostaglandin F_2α (PGF_2α) may differentially affect viability of luteal cells by inducing either proliferation or cell death (via apoptosis or necroptosis). The diverse effects of PGF_2α may depend on its local vs. systemic actions. In our study, we determined changes in expression of genes related to: (i) apoptosis: caspase (CASP) 3, CASP8, BCL2 associated X (BAX), B-cell lymphoma 2 (BCL2) and (ii) necroptosis: receptor-interacting protein kinase (RIPK) 1, RIPK3, cylindromatosis (CYLD), and mixed lineage kinase domain-like (MLKL) in the early and mid-stage corpus luteum (CL) that accompany local (intra-CL) vs. systemic (i.m.) analogue of PGF_2α (aPGF_2α) actions. Cows at day 4 (n = 24) or day 10 (n = 24) of the estrous

SUBMITTER: Jonczyk AW 

PROVIDER: S-EPMC6873574 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature