Impact of polymorphic transposable elements on transcription in lymphoblastoid cell lines from public data.

ABSTRACT:

Background

Transposable elements (TEs) are DNA sequences able to mobilize themselves and to increase their copy-number in the host genome. In the past, they have been considered mainly selfish DNA without evident functions. Nevertheless, currently they are believed to have been extensively involved in the evolution of primate genomes, especially from a regulatory perspective. Due to their recent activity they are also one of the primary sources of structural variants (SVs) in the human genome. By taking advantage of sequencing technologies and bioinformatics tools, recent surveys uncovered specific TE structural variants (TEVs) that gave rise to polymorphisms in human populations. When combined with RNA-seq data this information provides the opportunity to study the potential impac

SUBMITTER: Spirito G 

PROVIDER: S-EPMC6873650 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature