Genes with human-specific features are primarily involved with brain, immune and metabolic evolution.

ABSTRACT:

Background

Humans have adapted to widespread changes during the past 2 million years in both environmental and lifestyle factors. This is evident in overall body alterations such as average height and brain size. Although we can appreciate the uniqueness of our species in many aspects, molecular variations that drive such changes are far from being fully known and explained. Comparative genomics is able to determine variations in genomic sequence that may provide functional information to better understand species-specific adaptations. A large number of human-specific genomic variations have been reported but no currently available dataset comprises all of these, a problem which contributes to hinder progress in the field.

Results

Here we critically update high confidence hu

SUBMITTER: Bitar M 

PROVIDER: S-EPMC6873653 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature