Exploratory analysis of transposable elements expression in the C. elegans early embryo.

ABSTRACT:

Background

Transposable Elements (TE) are mobile sequences that make up large portions of eukaryote genomes. The functions they play within the complex cellular architecture are still not clearly understood, but it is becoming evident that TE have a role in several physiological and pathological processes. In particular, it has been shown that TE transcription is necessary for the correct development of mice embryos and that their expression is able to finely modulate transcription of coding and non-coding genes. Moreover, their activity in the central nervous system (CNS) and other tissues has been correlated with the creation of somatic mosaicisms and with pathologies such as neurodevelopmental and neurodegenerative diseases as well as cancers.

Results

We analyzed TE expre

SUBMITTER: Ansaloni F 

PROVIDER: S-EPMC6873666 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature