Inhibition of Plasmodium sporogonic stages by ivermectin and other avermectins.

ABSTRACT:

Background

The transmissible forms of Plasmodium parasites result from a process of sporogony that takes place inside their obligatory mosquito vector and culminates in the formation of mammalian-infective parasite forms. Ivermectin is a member of the avermectin family of endectocides, which has been proposed to inhibit malaria transmission due its insecticidal effect. However, it remains unclear whether ivermectin also exerts a direct action on the parasite's blood and transmission stages.

Methods

We employed a rodent model of infection to assess the impact of ivermectin treatment on P. berghei asexual and sexual blood forms in vivo. We then made use of a newly established luminescence-based methodology to evaluate the activity of ivermectin and other avermectins against th

SUBMITTER: Azevedo R 

PROVIDER: S-EPMC6873674 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature