Effect of nicotine 6 mg gum on urges to smoke, a randomized clinical trial.

ABSTRACT:

Background

Ability to manage urges to smoke is fundamental to maximizing the chances of success in smoking cessation. Previous studies have linked a higher dose of nicotine in nicotine replacement therapy to a higher success rate for smoking cessation. Thus, this study was performed to compare relief of urges to smoke, up until 5 h following treatment with a new 6 mg nicotine gum versus currently marketed 4 mg nicotine gum.

Methods

This was a randomized crossover clinical study. Following 12 h of abstinence from smoking, either one 6 mg or one 4 mg nicotine gum was given to 240 healthy adult smokers. Thereafter, urges to smoke were scored on a 100 mm Visual Analogue Scale repeatedly over 5 h.

Results

The reductions in urges to smoke over the first 1 and 3 h after admi

SUBMITTER: Hansson A 

PROVIDER: S-EPMC6873734 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature