Blp1 protein shows virulence-associated features and elicits protective immunity to Acinetobacter baumannii infection.

ABSTRACT:

Background

Multidrug resistant Acinetobacter baumannii is one of the major infection agents causing nosocomial pneumonia. Therefore, new therapeutic approaches against this bacterium are needed. Surface-exposed proteins from bacterial pathogens are implicated in a variety of virulence-related traits and are considered as promising candidates for vaccine development.

Results

We show in this study that a large Blp1 protein from opportunistic pathogen A. baumannii is encoded in all examined clinical strains of globally spread international clonal lineages I (IC I) and II (IC II). The two blp1 gene variants exhibit lineage-specific distribution profile. By characterization of blp1 deletion mutants and their complementation with blp1 alleles we show that blp1 gene is required for

SUBMITTER: Skerniskyte J 

PROVIDER: S-EPMC6873735 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature