Kinetic analysis of [18F] altanserin bolus injection in the canine brain using PET imaging.

ABSTRACT: BACKGROUND:Currently, [18F] altanserin is the most frequently used PET-radioligand for serotonin2A (5-HT2A) receptor imaging in the human brain but has never been validated in dogs. In vivo imaging of this receptor in the canine brain could improve diagnosis and therapy of several behavioural disorders in dogs. Furthermore, since dogs are considered as a valuable animal model for human psychiatric disorders, the ability to image this receptor in dogs could help to increase our understanding of the pathophysiology of these diseases. Therefore, five healthy laboratory beagles underwent a 90-min dynamic PET scan with arterial blood sampling after [18F] altanserin bolus injection. Compartmental modelling using metabolite corrected arterial input functions was compared with reference tissue mod

SUBMITTER: Pauwelyn G 

PROVIDER: S-EPMC6873736 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature