Association between lncRNA H19 rs217727 polymorphism and the risk of cancer: an updated meta-analysis.

ABSTRACT:

Background

We have performed this study to evaluate the association between H19 rs217727 polymorphism and the risk of cancer.

Methods

An odds ratio (OR) with a 95% confidence interval (CI) was applied to determine a potential association.

Results

A total of 17 case-control publications were selected. This meta-analysis showed that H19 rs217727 has a significant increased association with cancer risk in allelic, homozygous, heterozygote, dominant and recessive models (T vs C: OR = 1.16, 95% CI = 1.06-1.27, I² = 75.7; TT vs CC: OR = 1.29, 95% CI = 1.06-1.56, I² = 71.6; CT vs CC: OR = 1.15, 95% CI = 1.01-1.31, I² = 75.4; CT + TT vs CC: OR = 1.20, 95% CI = 1.05-1.36, I² = 76.5; TT vs CT + CC: OR = 1.22, 95% CI = 1.02-1.45, I

SUBMITTER: Wang X 

PROVIDER: S-EPMC6873771 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature