Optimal Stimulation Protocol in a Bistable Synaptic Consolidation Model.

ABSTRACT: Synaptic changes induced by neural activity need to be consolidated to maintain memory over a timescale of hours. In experiments, synaptic consolidation can be induced by repeating a stimulation protocol several times and the effectiveness of consolidation depends crucially on the repetition frequency of the stimulations. We address the question: is there an understandable reason why induction protocols with repetitions at some frequency work better than sustained protocols-even though the accumulated stimulation strength might be exactly the same in both cases? In real synapses, plasticity occurs on multiple time scales from seconds (induction), to several minutes (early phase of long-term potentiation) to hours and days (late phase of synaptic consolidation). We use a simplified mathemat

SUBMITTER: Gastaldi C 

PROVIDER: S-EPMC6874130 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature