Incorporating NTCP into Randomized Trials of Proton Versus Photon Therapy.

ABSTRACT:

Purpose

We propose and simulate a model-based methodology to incorporate heterogeneous treatment benefit of proton therapy (PrT) versus photon therapy into randomized trial designs. We use radiation-induced pneumonitis (RP) as an exemplar. The aim is to obtain an unbiased estimate of how predicted difference in normal tissue complications probability (ΔNTCP) converts into clinical outcome on the patient level.

Materials and methods

ΔNTCP data from in silico treatment plans for photon therapy and PrT for patients with locally advanced lung cancer as well as randomly sampled clinical risk factors were included in simulations of trial outcomes. The model used at point of analysis of the trials was an iQUANTEC model. Trial outcomes were examined with Cox proportional hazards mod

SUBMITTER: Scherman J 

PROVIDER: S-EPMC6874185 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature