Liquid Chromatography/Mass Spectrometry based serum metabolomics study on recurrent abortion women with antiphospholipid syndrome.

ABSTRACT:

Objective

The antiphospholipid syndrome (APS) is an important cause of acquired thromboembolic complications and pregnancy morbidity. The pathogenic mechanisms that damage the fetal-maternal unit and cause abnormal placental development are incompletely understood in APS patients. Liquid Chromatography/Mass Spectrometry (LC/MS) based metabolomics are applied for the mechanism of disease and further supporting the research of diagnosis and management in recent years. The aim of this research was to investigate the difference of serum metabolic profiles in recurrent abortion women with APS and healthy women to explore the mechanism of this disease.

Methods

Serum samples of 25 recurrent abortion women with APS and 25 healthy women were collected and analyzed by LC/MS in this st

SUBMITTER: Zhang L 

PROVIDER: S-EPMC6874207 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature