Pd-catalyzed arylation of linear and angular spirodiamine salts under aerobic conditions.

ABSTRACT: Application of Buchwald-Hartwig catalysis for development of biologically relevant arylspirodiamine compounds is reported. This synthetic methodology requires no inert atmosphere and affords yields up to 93% in just 20 min. Linear and sterically hindered angular spirodiamines in salt and free-base form are coupled with electron-rich and -withdrawing aryl chlorides, demonstrating a broad scope and applicability of this protocol.

SUBMITTER: Reilly SW 

PROVIDER: S-EPMC6874415 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature