Bioinformatic profiling of prognosis-related genes in the breast cancer immune microenvironment.

ABSTRACT: In the microenvironment of breast cancer, immune cell infiltration is associated with an improved prognosis. To identify immune-related prognostic markers and therapeutic targets, we determined the lymphocyte-specific kinase (LCK) metagene scores of samples from breast cancer patients in The Cancer Genome Atlas. The LCK metagene score correlated highly with other immune-related scores, as well as with the clinical stage, prognosis and tumor suppressor gene mutation status (BRCA2, TP53, PTEN) of patients in the four breast cancer subtypes. A weighted gene co-expression network analysis was performed to detect representative genes from LCK metagene-related gene modules. In two of these modules, the levels of the co-expressed genes correlated highly with LCK metagene leve

SUBMITTER: Bai F 

PROVIDER: S-EPMC6874454 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature