Bone marrow adipose tissue does not express UCP1 during development or adrenergic-induced remodeling.

ABSTRACT: Adipocytes within the skeleton are collectively termed bone marrow adipose tissue (BMAT). BMAT contributes to peripheral and local metabolism, however, its capacity for cell-autonomous expression of uncoupling protein 1 (UCP1), a biomarker of beige and brown adipogenesis, remains unclear. To overcome this, Ucp1-Cre was used to drive diphtheria toxin expression in cells expressing UCP1 (Ucp1^Cre+/DTA+). Despite loss of brown adipose tissue, BMAT volume was not reduced in Ucp1^Cre+/DTA+ mice. Comparably, in mTmG reporter mice (Ucp1^Cre+/mTmG+), Ucp1-Cre expression was absent from BMAT in young (3-weeks) and mature (16-weeks) male and female mice. Further, β3-agonist stimulation failed to induce Ucp1-Cre expression in BMAT. This demonstrates that BMAT adipocytes

SUBMITTER: Craft CS 

PROVIDER: S-EPMC6874537 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature