Infant cardiosphere-derived cells exhibit non-durable heart protection in dilated cardiomyopathy rats.

ABSTRACT: Stem cells provide a new strategy for the treatment of cardiac diseases; however, their effectiveness in dilated cardiomyopathy (DCM) has not been investigated. In this study, cardiosphere-derived cells (CDCs) were isolated from infants (≤ 24 months) and identified by the cell surface markers CD105, CD90, CD117 and CD45, which is consistent with a previous report, although increased CD34 expression was observed. The molecular expression profile of CDCs from infants was determined by RNA sequencing and compared with adult CDCs, showing that infant CDCs have almost completely altered gene expression patterns compared with adult CDCs. The upregulated genes in infant CDCs are mainly related to the biological processes of cell morphogenesis and differentiation. The molecular profile of infant C

SUBMITTER: Wang S 

PROVIDER: S-EPMC6874636 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature