Genetic variation associated with infection and the environment in the accidental pathogen Burkholderia pseudomallei.

ABSTRACT: The environmental bacterium Burkholderia pseudomallei causes melioidosis, an important endemic human disease in tropical and sub-tropical countries. This bacterium occupies broad ecological niches including soil, contaminated water, single-cell microbes, plants and infection in a range of animal species. Here, we performed genome-wide association studies for genetic determinants of environmental and human adaptation using a combined dataset of 1,010 whole genome sequences of B. pseudomallei from Northeast Thailand and Australia, representing two major disease hotspots. With these data, we identified 47 genes from 26 distinct loci associated with clinical or environmental isolates from Thailand and replicated 12 genes in an independent Australian cohort. We next outlined the s

SUBMITTER: Chewapreecha C 

PROVIDER: S-EPMC6874650 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature