Lupus-like Disease in FcγRIIB^-/- Mice Induces Osteopenia.

ABSTRACT: Osteoporotic fracture is a major cause of morbidity in patients with systemic lupus erythematosus (SLE). Mice lacking Fc gamma receptor IIb (FcγRIIB) spontaneously develop lupus-like disease or SLE at 6-month-old. The aim of this study was to investigate whether FcγRIIB deletion induces osteopenia. μCT analysis indicated that deleting FcγRIIB did not affect cancellous bone microarchitecture in 3-month-old mice in which SLE had not yet developed. However, 6- and 10-month-old FcγRIIB^-/- males that developed an SLE-like phenotype were osteopenic and FcγRIIB deletion resulted in decreased cancellous bone volume. Histomorphometry confirmed a significant decrease in cancellous bone volume in 6- and 10-month-old FcγRIIB^-/- males. The osteoclast number was increased without a

SUBMITTER: Visitchanakun P 

PROVIDER: S-EPMC6874658 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature